Hydrochloric Acid

Hydrochloric Acid

SCHEMBL9525472

CCC[n+]1cc(Br)cc(C(=O)N(CCCC(=O)NCCOC(=O)Nc2cccc3ccccc23)c2ccccc2)c1.[Cl-]

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
HPGD P15428 1/20 0.38
LMNA P02545 1/20 0.35
EPHX1 P07099 1/20 0.34
MTNR1A P48039 4/20 0.34
KDM4E B2RXH2 2/20 0.34
KMT2A Q03164 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
MTNR1B P49286 2/20 0.33
HDAC3 O15379 2/20 0.33
HDAC4 P56524 2/20 0.33
HDAC1 Q13547 2/20 0.33
HDAC7 Q8WUI4 2/20 0.33
HDAC2 Q92769 2/20 0.33
HDAC10 Q969S8 2/20 0.33
HDAC11 Q96DB2 2/20 0.33
HDAC8 Q9BY41 2/20 0.33
HDAC6 Q9UBN7 2/20 0.33
HDAC9 Q9UKV0 2/20 0.33
HDAC5 Q9UQL6 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9525020 0.96 ALDH1A1 (0.39) ALDH1A1HPGDEPHX1MTNR1AKDM4E
SCHEMBL9525126 0.95 ALDH1A1 (0.40) ALDH1A1HPGDEPHX1MTNR1AKDM4E
Hydrochloric Acid SCHEMBL9524484 0.93 ALDH1A1 (0.39) ALDH1A1HPGDEPHX1KDM4EKMT2A
Hydrochloric Acid SCHEMBL9524164 0.91 ALDH1A1 (0.41) ALDH1A1HPGDLMNAEPHX1KDM4E
Hydrochloric Acid SCHEMBL9524100 0.91 ALDH1A1 (0.40) ALDH1A1HPGDLMNAEPHX1MTNR1A
Iodide SCHEMBL9525383 0.90 ALDH1A1 (0.41) ALDH1A1HPGDLMNAEPHX1KDM4E
Hydrochloric Acid SCHEMBL9528179 0.90 ALDH1A1 (0.37) ALDH1A1HPGDLMNAEPHX1KDM4E
Hydrochloric Acid SCHEMBL9525737 0.90 ALDH1A1 (0.44) ALDH1A1HPGDLMNAEPHX1KDM4E
Hydrochloric Acid SCHEMBL9524109 0.88 ALDH1A1 (0.39) ALDH1A1HPGDLMNAEPHX1KDM4E
Hydrochloric Acid SCHEMBL9524281 0.88 ALDH1A1 (0.39) ALDH1A1HPGDLMNAEPHX1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0301751-B1 PYRIDINIUM DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1993-03-10 EP disclosed
US-4962113-A PLATELET ACTIVATING FACTOR ANTAGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD (JP) 1990-10-09 US disclosed
EP-0301751-A1 Pyridinium derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1989-02-01 EP disclosed