SCHEMBL9525745

SCHEMBL9525745

CC1(C)CC(c2nccc[n+]2[O-])c2cc(C#N)ccc2O1

nearest known ligand 0.39

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 10/20 0.39
ABCC9 O60706 4/20 0.38
SIRT2 Q8IXJ6 2/20 0.35
SIRT1 Q96EB6 1/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9524801 0.82 ABCC9 (0.45) ABCB1ABCC9SIRT2
SCHEMBL8174399 0.82 ABCB1 (0.40) ABCB1ABCC9SIRT2KDM4E
SCHEMBL8174878 0.82 ABCB1 (0.40) ABCB1ABCC9SIRT2KDM4E
SCHEMBL8174728 0.82 ABCB1 (0.40) ABCB1ABCC9SIRT2KDM4E
SCHEMBL8967989 0.79 ABCC9 (0.43) ABCB1ABCC9SIRT2KDM4E
SCHEMBL8338287 0.79 ABCC9 (0.43) ABCB1ABCC9SIRT2KDM4E
SCHEMBL9525755 0.79 ABCC9 (0.40) ABCB1ABCC9KDM4E
SCHEMBL9524591 0.78 ABCB1 (0.39) ABCB1ABCC9KDM4E
SCHEMBL9523798 0.78 ABCB1 (0.40) ABCB1ABCC9SIRT2KDM4E
SCHEMBL9628037 0.77 ABCB1 (0.38) ABCB1ABCC9SIRT2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0298452-B1 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL F. HOFFMANN-LA ROCHE AG (CH) 1993-06-30 EP claimed
US-5118694-A Hypotensive agents; treatment for cardiovascular and muscular disorders HOFFMANN-LA ROCHE INC. (US) 1992-06-02 US claimed
US-5118694-A Hypotensive agents; treatment for cardiovascular and muscular disorders HOFFMANN-LA ROCHE INC. (US) 1992-06-02 US disclosed
US-4971982-A HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS HOFFMANN-LA ROCHE INC. (US) 1990-11-20 US disclosed