Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524435 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10539747 | 0.79 | KDM4E (0.69) | SMN1; SMN2ALDH1A1PKMHPGDNPSR1 | |
| SCHEMBL9525624 | 0.78 | HTR4 (0.48) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10542037 | 0.76 | CYP2D6 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10537786 | 0.75 | MAPT (0.67) | MEN1KMT2AALDH1A1ATMMAPT | |
| SCHEMBL10541780 | 0.75 | CYP2D6 (0.54) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL10542205 | 0.75 | POLB (0.60) | SMN1; SMN2KMT2AALDH1A1PKMMAPT | |
| SCHEMBL10539974 | 0.74 | MAPT (0.56) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL9526020 | 0.74 | HTR4 (0.47) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9396711 | 0.72 | PKM (0.67) | SMN1; SMN2MEN1KMT2APKMATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255297-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | BEECHAM GROUP PLC (GB) | 1993-04-21 | — | — | EP | claimed |
| EP-0255297-A2 | Azabicyclic compounds, process for their preparation, and their pharmaceutical use | BEECHAM GROUP PLC (GB) | 1988-02-03 | — | — | EP | claimed |
| EP-0255297-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | BEECHAM GROUP PLC (GB) | 1993-04-21 | — | — | EP | disclosed |
| US-4808588-A | HEADACHES, CENTRAL NERVOUS SYSTEM DISORDERS, ANTIARRHYTHMIA ANTIEMETIC AGENTS | BEECHAM GROUP, P.L.C. (GB) | 1989-02-28 | — | — | US | disclosed |