Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 1.00 |
| ▸ | CES1 | P23141 | 4/20 | 1.00 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.85 |
| ▸ | HSD11B2 | P80365 | 5/20 | 0.85 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.85 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.85 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.69 |
| ▸ | CNR1 | P21554 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.67 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9653309 | 1.00 | CES2 (1.00) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| Acetoxolone SCHEMBL420037 | 0.92 | HSD11B1 (1.00) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| Acetoxolone SCHEMBL11785821 | 0.92 | HSD11B1 (1.00) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| Acetoxolone SCHEMBL420036 | 0.92 | HSD11B1 (1.00) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| Acetoxolone SCHEMBL135617 | 0.92 | HSD11B1 (1.00) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| SCHEMBL16003486 | 0.91 | HSD11B1 (0.85) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| SCHEMBL22571029 | 0.91 | HSD11B1 (0.85) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| SCHEMBL9342334 | 0.91 | HSD11B1 (0.85) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| SCHEMBL9652506 | 0.91 | HSD11B1 (0.85) | CES2CES1HSD11B1HSD11B2HSD17B1 | |
| SCHEMBL9342337 | 0.91 | HSD11B1 (0.85) | CES2CES1HSD11B1HSD11B2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272478-B1 | GLYCYRRHETIC ACID DERIVATIVES AND USE THEREOF | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-4871740-A | ANTIULCER AGENT; REDUCTION OF SIDE EFFECTS FROM STEROIDS | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-10-03 | — | — | US | disclosed |
| EP-0272478-A1 | Glycyrrhetic acid derivatives and use thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1988-06-29 | — | — | EP | disclosed |