Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526011 | 1.00 | MAPT (0.64) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL23251385 | 0.87 | MAPT (0.81) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL11076540 | 0.85 | ALDH1A1 (0.66) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL325285 | 0.84 | ALDH1A1 (0.68) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL325284 | 0.84 | ALDH1A1 (0.68) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL7364598 | 0.79 | MAPT (0.70) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL801273 | 0.79 | MAPT (0.70) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL1186589 | 0.79 | MAPT (0.70) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL1186588 | 0.79 | MAPT (0.70) | MAPTRAB9ALMNAHPGDCYP1A2 | |
| SCHEMBL12914243 | 0.79 | MAPT (0.70) | MAPTRAB9ALMNAHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259972-B1 | HETEROCYCLIC PROPENE AMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | LILLY INDUSTRIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |