Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | IDH1 | O75874 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.57 |
| ▸ | FLT4 | P35916 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467685 | 0.89 | HSD17B10 (0.61) | MEN1KMT2AHSD17B10PPARGNPC1 | |
| SCHEMBL9486495 | 0.88 | CA12 (0.66) | MEN1KMT2APPARGFLT1FLT4 | |
| SCHEMBL5187356 | 0.87 | CA12 (0.70) | EGFRMEN1KMT2AHSD17B10PPARG | |
| SCHEMBL9526067 | 0.86 | POLB (0.76) | EGFRERBB2MEN1KMT2AHSD17B10 | |
| SCHEMBL8621686 | 0.86 | LMNA (0.62) | EGFRERBB2MEN1KMT2AHSD17B10 | |
| SCHEMBL7777663 | 0.86 | LMNA (0.71) | EGFRERBB2HSD17B10NPC1POLB | |
| SCHEMBL9485899 | 0.85 | CYP3A4 (0.55) | MEN1KMT2AHSD17B10POLBCA12 | |
| SCHEMBL8662949 | 0.85 | HRH3 (0.72) | HSD17B10NPC1POLBCA12CA1 | |
| SCHEMBL6467353 | 0.85 | SAE1 (0.71) | EGFRERBB2HSD17B10NPC1POLB | |
| SCHEMBL9485939 | 0.84 | FLT1 (0.62) | MEN1KMT2AIDH1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166615-B1 | IMPROVEMENTS IN OR RELATING TO BENZENESULFONAMIDO DERIVATIVES | ELI LILLY AND COMPANY (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5110830-A | Benzenesulfonamides treatment of tumors susceptible to | ELI LILLY AND COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-4845128-A | ANTITUMOR | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0166615-A2 | Improvements in or relating to benzenesulfonamido derivatives | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |