Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522447 | 0.87 | MAPT (0.41) | TP53MAPTRAB9AL3MBTL1KMT2A | |
| SCHEMBL9827275 | 0.87 | TP53 (0.41) | TP53MAPTPOLBRAB9AL3MBTL1 | |
| SCHEMBL9522273 | 0.86 | TP53 (0.40) | TP53MAPTRAB9AL3MBTL1KMT2A | |
| SCHEMBL9522270 | 0.86 | TP53 (0.40) | TP53MAPTRAB9AL3MBTL1KMT2A | |
| SCHEMBL9832040 | 0.86 | TP53 (0.43) | TP53MAPTRAB9AL3MBTL1KMT2A | |
| SCHEMBL9522928 | 0.86 | TP53 (0.42) | TP53MAPTRAB9AL3MBTL1KMT2A | |
| SCHEMBL8111901 | 0.86 | TP53 (0.42) | TP53MAPTRAB9AL3MBTL1KMT2A | |
| SCHEMBL9832793 | 0.85 | TP53 (0.46) | TP53MAPTRAB9AL3MBTL1KMT2A | |
| SCHEMBL9525407 | 0.85 | MAPT (0.41) | TP53MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL9522614 | 0.84 | MAPT (0.43) | TP53MAPTRAB9AL3MBTL1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5166152-A | Immunostimulants, bactericides, viricides, antitumor agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-24 | — | — | US | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |