Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.62 |
| ▸ | FEN1 | P39748 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1427082 | 0.84 | ERCC5 (0.59) | ALDH1A1MAPK1HIF1AERCC5FEN1 | |
| SCHEMBL4449153 | 0.83 | ERCC5 (0.62) | ALDH1A1MAPK1HIF1AERCC5FEN1 | |
| SCHEMBL29481555 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MAPK1HIF1AERCC5FEN1 | |
| SCHEMBL1691536 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MAPK1HIF1AERCC5FEN1 | |
| SCHEMBL404490 | 0.82 | ERCC5 (0.61) | ALDH1A1MAPK1HIF1AERCC5FEN1 | |
| SCHEMBL29391618 | 0.82 | ERCC5 (0.61) | ALDH1A1MAPK1HIF1AERCC5FEN1 | |
| SCHEMBL1154685 | 0.82 | MAPK1 (0.63) | ALDH1A1MAPK1HIF1ATP53LMNA | |
| SCHEMBL11613851 | 0.82 | ALDH1A1 (0.61) | ALDH1A1MAPK1HIF1AERCC5FEN1 | |
| SCHEMBL21055979 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MAPK1HIF1AERCC5FEN1 | |
| SCHEMBL16770754 | 0.82 | ERCC5 (0.61) | ALDH1A1MAPK1HIF1AERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243081-A | Pyrido[2,3-d]pyrimidine-2,4-diamine compounds as PTP1B inhibitors | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |
| EP-0365913-B1 | Substituted 2-aminothiazoles | BAYER AG (DE) | 1993-11-18 | — | — | EP | disclosed |
| US-5104879-A | ANTIMYCOTICALLY ACTIVE SUBSTITUTED 2-AMINOTHIAZOLES | BAYER AKTIENGESELLSCHAFT (DE) | 1992-04-14 | — | — | US | disclosed |
| EP-0365913-A2 | Substituted 2-aminothiazoles | BAYER AG (DE) | 1990-05-02 | — | — | EP | disclosed |