Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 5/20 | 0.47 |
| ▸ | CA7 | P43166 | 5/20 | 0.47 |
| ▸ | CA9 | Q16790 | 5/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11622247 | 0.84 | GSK3B (0.60) | GSK3BNR1H2NR1H3ALOX15CA12 | |
| SCHEMBL2028240 | 0.83 | ALOX15 (0.61) | GSK3BALOX15HPGDSMN1; SMN2NPC1 | |
| SCHEMBL10288389 | 0.82 | GSK3B (0.59) | GSK3BNR1H2NR1H3ALOX15CA12 | |
| SCHEMBL7670938 | 0.81 | TSHR (0.45) | GSK3BCA12CA1CA2CA7 | |
| SCHEMBL10712475 | 0.80 | MAPT (0.61) | ALOX15HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL17203079 | 0.76 | GSK3B (0.52) | GSK3BNR1H2NR1H3ALOX15CA12 | |
| SCHEMBL17977274 | 0.75 | MAPT (0.48) | GSK3BALOX15HPGDSMN1; SMN2NPC1 | |
| SCHEMBL8929358 | 0.74 | CYP3A4 (0.43) | GSK3BCYP3A4HPGDSMN1; SMN2KMT2A | |
| SCHEMBL1141274 | 0.74 | GAA (0.56) | GSK3BALOX15CA12CA1CA2 | |
| SCHEMBL1726035 | 0.72 | GAA (0.55) | GSK3BALOX15HPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297697-B1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1993-12-29 | — | — | EP | disclosed |
| US-4904686-A | 3-ALKOXYTHIOPHENE-2-CARBOXAMIDES; CENTRAL NERVOUS SYSTEM DISORDERS | LILLY INDUSTRIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |
| EP-0297697-A1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1989-01-04 | — | — | EP | disclosed |