SCHEMBL10712475

SCHEMBL10712475

CCOC(=O)c1sc(C)cc1N

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.61
ALDH1A1 P00352 9/20 0.61
RAB9A P51151 6/20 0.61
KDM4E B2RXH2 6/20 0.61
NPC1 O15118 5/20 0.61
MEN1 O00255 5/20 0.61
KMT2A Q03164 5/20 0.61
SMN1; SMN2 Q16637 5/20 0.61
HPGD P15428 5/20 0.61
HSD17B10 Q99714 5/20 0.61
CYP1A2 P05177 2/20 0.58
TP53 P04637 1/20 0.58
CASP3 P42574 1/20 0.58
SENP8 Q96LD8 1/20 0.58
SENP7 Q9BQF6 1/20 0.58
SENP6 Q9GZR1 1/20 0.58
CYP2C9 P11712 1/20 0.58
CYP2C19 P33261 1/20 0.58
RECQL P46063 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38152 0.84 MAPT (0.60) MAPTALDH1A1RAB9AKDM4ENPC1
SCHEMBL1531268 0.83 MAPT (0.63) MAPTALDH1A1RAB9AKDM4ENPC1
SCHEMBL2028240 0.81 ALOX15 (0.61) MAPTALDH1A1RAB9AKDM4ENPC1
SCHEMBL166726 0.81 MAPT (0.54) MAPTALDH1A1RAB9AKDM4ENPC1
SCHEMBL7842072 0.81 ALDH1A1 (0.62) MAPTALDH1A1RAB9AKDM4ENPC1
SCHEMBL6119541 0.80 ALDH1A1 (0.56) MAPTALDH1A1RAB9AKDM4ENPC1
SCHEMBL1883586 0.80 MAPT (0.56) MAPTALDH1A1RAB9AKDM4ENPC1
SCHEMBL8815118 0.80 MAPT (0.56) MAPTALDH1A1RAB9AKDM4ENPC1
SCHEMBL9526227 0.80 GSK3B (0.62) MAPTALDH1A1RAB9AKDM4ENPC1
Hydrochloric Acid SCHEMBL10735502 0.80 MAPT (0.53) MAPTALDH1A1RAB9AKDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0986382-B1 RAF KINASE INHIBITORS BAYER PHARMACEUTICALS CORP (US) 2008-06-25 EP disclosed
EP-0198206-B1 AZO DYES BAYER AG (DE) 1988-10-26 EP disclosed
US-4711954-A FOR POLYAMIDES; COLORFASTNESS BAYER AKTIENGESELLSCHAFT (DE) 1987-12-08 US disclosed
EP-0198206-A1 Azo dyes BAYER AG (DE) 1986-10-22 EP disclosed