Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.44 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526268 | 1.00 | PLA2G10 (0.44) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 | |
| SCHEMBL8921216 | 0.84 | RAMP1 (0.50) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 | |
| SCHEMBL13929747 | 0.84 | RAMP1 (0.50) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 | |
| SCHEMBL10377805 | 0.84 | ALDH1A1 (0.40) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL9527202 | 0.84 | PLA2G10 (0.42) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 | |
| SCHEMBL10377803 | 0.84 | ALDH1A1 (0.40) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL9527199 | 0.84 | PLA2G10 (0.42) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 | |
| SCHEMBL7344553 | 0.83 | SIGMAR1 (0.36) | RIPK1SIGMAR1 | |
| SCHEMBL7344546 | 0.83 | SIGMAR1 (0.36) | RIPK1SIGMAR1 | |
| SCHEMBL8924459 | 0.82 | PLA2G10 (0.44) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365045-B1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| EP-0161801-B1 | PERHYDROTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANKYO COMPANY LIMITED (JP) | 1990-11-07 | — | — | EP | disclosed |
| EP-0365045-A1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4699905-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0161801-A2 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1985-11-21 | — | — | EP | disclosed |