Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526572 | 1.00 | TSHR (0.39) | TSHRLMNAAHRTAAR1L3MBTL1 | |
| SCHEMBL10980854 | 0.83 | TSHR (0.52) | TSHRLMNATAAR1L3MBTL1SLC6A2 | |
| SCHEMBL10978067 | 0.83 | TSHR (0.52) | TSHRLMNATAAR1L3MBTL1SLC6A2 | |
| SCHEMBL10978073 | 0.83 | TSHR (0.52) | TSHRLMNATAAR1L3MBTL1SLC6A2 | |
| SCHEMBL10980851 | 0.83 | TSHR (0.52) | TSHRLMNATAAR1L3MBTL1SLC6A2 | |
| SCHEMBL9570489 | 0.83 | LMNA (0.42) | TSHRLMNATAAR1L3MBTL1SLC6A2 | |
| SCHEMBL9525618 | 0.83 | LMNA (0.42) | TSHRLMNATAAR1L3MBTL1SLC6A2 | |
| SCHEMBL9525628 | 0.83 | LMNA (0.42) | TSHRLMNATAAR1L3MBTL1SLC6A2 | |
| SCHEMBL10377076 | 0.80 | ALDH1A1 (0.42) | TSHRLMNA | |
| SCHEMBL10377075 | 0.80 | ALDH1A1 (0.42) | TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359290-B1 | AROMATIC DIOLS | GLAXO GROUP LIMITED (GB) | 1993-08-04 | — | — | EP | disclosed |
| EP-0162593-B1 | HETEROCYCLIC AMINO COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1990-08-16 | — | — | EP | disclosed |
| EP-0359290-A1 | Aromatic diols | GLAXO GROUP LIMITED (GB) | 1990-03-21 | — | — | EP | disclosed |
| EP-0162593-A1 | Heterocyclic amino compounds | GLAXO GROUP LIMITED (GB) | 1985-11-27 | — | — | EP | disclosed |