Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RHOC | P08134 | 1/20 | 0.38 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.37 |
| ▸ | GABRP | O00591 | 3/20 | 0.37 |
| ▸ | GABRD | O14764 | 3/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.37 |
| ▸ | GABRE | P78334 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372959 | 0.89 | BACE1 (0.43) | BACE1GABRA2GABRB2LMNAALDH1A1 | |
| SCHEMBL9822782 | 0.85 | GABRB3 (0.45) | BACE1GABRA2GABRB2ALDH1A1GABRB3 | |
| SCHEMBL10560567 | 0.82 | SMN1; SMN2 (0.43) | BACE1GABRA2GABRB2LMNAALDH1A1 | |
| SCHEMBL10668017 | 0.79 | MAPT (0.50) | LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10411191 | 0.79 | BACE1 (0.39) | BACE1GABRA2GABRB2RHOCRHOA | |
| SCHEMBL10563948 | 0.78 | BACE1 (0.40) | BACE1GABRA2GABRB2LMNANPSR1 | |
| SCHEMBL9527645 | 0.78 | BACE1 (0.42) | BACE1GABRA2GABRB2GABRB3GABRP | |
| SCHEMBL10388695 | 0.75 | MAPT (0.37) | HDAC1HDAC8GABRA2GABRB2NPSR1 | |
| SCHEMBL10400135 | 0.75 | BACE1 (0.42) | BACE1GABRA2GABRB2NPSR1ALDH1A1 | |
| SCHEMBL10668725 | 0.75 | TSHR (0.50) | BACE1NPSR1ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392241-B1 | SUBSTITUTED 1-ARYLPYRAZOLS | BAYER AG (DE) | 1993-06-02 | — | — | EP | disclosed |
| US-4971989-A | PESTICIDES, MITICIDES, INSECTICIDES AND NEMATOCIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-20 | — | — | US | disclosed |
| EP-0392241-A1 | Substituted 1-Arylpyrazols | BAYER AG (DE) | 1990-10-17 | — | — | EP | disclosed |