Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527153 | 1.00 | MMP3 (0.43) | MMP3AGTR1AGTR2ALOX5APFEN1 | |
| SCHEMBL7815799 | 0.80 | MME (0.40) | AGTR1AGTR2 | |
| SCHEMBL7815803 | 0.80 | MME (0.40) | AGTR1AGTR2 | |
| SCHEMBL9525529 | 0.80 | HRH2 (0.40) | — | |
| SCHEMBL9525532 | 0.80 | HRH2 (0.40) | — | |
| SCHEMBL9592769 | 0.72 | ALOX5AP (0.43) | ALOX5APFEN1 | |
| SCHEMBL9592764 | 0.72 | ALOX5AP (0.43) | ALOX5APFEN1 | |
| SCHEMBL9753984 | 0.70 | MME (0.44) | AGTR1AGTR2 | |
| SCHEMBL9753986 | 0.70 | MME (0.44) | AGTR1AGTR2 | |
| SCHEMBL8724087 | 0.69 | GAA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262412-A | Angiotensin II antagonists, hypotensive agents, treatment of congestive heart failure and glaucoma | MERCK & CO., INC. (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0523141-A4 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | — | 1993-04-21 | — | — | EP | disclosed |
| EP-0523141-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991015479-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO., INC. (US) | 1991-10-17 | — | — | WO | disclosed |