Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.33 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15427894 | 0.85 | LMNA (0.44) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL15675346 | 0.79 | KMT2A (0.39) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL15427902 | 0.78 | LMNA (0.44) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL9699037 | 0.75 | LMNA (0.50) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL31424565 | 0.73 | ERN1 (0.35) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL14268119 | 0.73 | TSHR (0.45) | KMT2AMEN1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL5346211 | 0.73 | ALDH1A1 (0.40) | LMNABLMTDP1ALDH1A1TSHR | |
| SCHEMBL28273863 | 0.72 | TSHR (0.59) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL29789973 | 0.72 | CYP3A4 (0.48) | KMT2AMEN1TDP1ALDH1A1TSHR | |
| SCHEMBL28616270 | 0.72 | FFAR1 (0.37) | ALDH1A1L3MBTL1HTTPTGES2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245918-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | GLAXO S.p.A. (IT) | 1993-05-05 | — | — | EP | disclosed |
| US-4946851-A | 1.4-dihydropyridines | GLAXO, S.P.A. (IT) | 1990-08-07 | — | — | US | disclosed |
| EP-0245918-A1 | 1,4-Dihydropyridine derivatives | GLAXO S.p.A. (IT) | 1987-11-19 | — | — | EP | disclosed |