Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22260783 | 0.86 | ALDH1A1 (0.45) | ALDH1A1POLBSMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL9051575 | 0.86 | ALDH1A1 (0.75) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL20043769 | 0.86 | ALDH1A1 (0.45) | ALDH1A1POLBSMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL2826555 | 0.82 | ALDH1A1 (0.48) | ALDH1A1POLBSMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL17343101 | 0.79 | ALDH1A1 (0.46) | ALDH1A1POLBTSHRCASP1BRCA1 | |
| SCHEMBL9526176 | 0.79 | ALDH1A1 (0.46) | ALDH1A1POLBTSHRCASP1BRCA1 | |
| Mitindomide SCHEMBL4171 | 0.75 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2TSHRCASP1BRCA1 | |
| Mitindomide SCHEMBL19411825 | 0.75 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2TSHRCASP1BRCA1 | |
| SCHEMBL3198101 | 0.70 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL4488756 | 0.70 | POLB (0.41) | ALDH1A1POLBSMN1; SMN2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220873-B1 | Fused bicyclic imides with psychotropic activity | AMERICAN HOME PROD (US) | 1993-11-24 | — | — | EP | disclosed |
| US-4957913-A | N-((4-ARYLPIPERAZINO)ALKYL) SUBSTITTUTED | AMERICAN HOME PRODUCTS CORP. (US) | 1990-09-18 | — | — | US | disclosed |
| US-4892943-A | ANTIPSYCHOTIC, ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-01-09 | — | — | US | disclosed |
| EP-0220873-A1 | Fused bicyclic imides with psychotropic activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-06 | — | — | EP | disclosed |