Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.66 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527688 | 0.91 | HTR1A (0.62) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9526736 | 0.91 | ADRA1A (0.62) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9526823 | 0.85 | HTR1A (0.64) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527346 | 0.85 | ADRA1A (0.65) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527309 | 0.85 | HTR1A (0.65) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527725 | 0.84 | HTR1A (0.60) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527250 | 0.83 | HTR1A (0.59) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9528533 | 0.83 | ADRA1A (0.71) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527896 | 0.82 | HTR1A (0.62) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL14761537 | 0.80 | ADRA1A (0.67) | HTR1AADRA1AADRA1DADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |