Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PNLIP | P16233 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523496 | 0.86 | FLT3 (0.60) | HIF1AFLT3NPC1RAB9AMAPT | |
| SCHEMBL9524412 | 0.85 | ADORA3 (0.54) | ADORA3NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9524562 | 0.85 | ADORA3 (0.59) | ADORA3FLT3CYP3A4NPC1RAB9A | |
| SCHEMBL9524233 | 0.85 | DHODH (0.54) | ADORA3HIF1ACDK2FLT3NPC1 | |
| SCHEMBL9524877 | 0.85 | ADORA3 (0.56) | ADORA3HIF1ACDK2FLT3CYP3A4 | |
| SCHEMBL9525863 | 0.83 | RAB9A (0.49) | ADORA3NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9527446 | 0.83 | ADORA3 (0.51) | ADORA3RAB9AMAPTPKMMEN1 | |
| SCHEMBL9524531 | 0.83 | HIF1A (0.54) | ADORA3HIF1ANPC1RAB9AMAPT | |
| SCHEMBL9523892 | 0.81 | HIF1A (0.53) | ADORA3HIF1ACYP3A4NPC1RAB9A | |
| SCHEMBL9525813 | 0.81 | MEN1 (0.50) | ADORA3NPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |