Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.39 |
| ▸ | TACR3 | P29371 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527595 | 0.92 | NCEH1 (0.42) | NCEH1TACR3POLBCHRNB2CHRNB4 | |
| SCHEMBL10370877 | 0.89 | TACR3 (0.39) | TACR3POLB | |
| SCHEMBL9529074 | 0.89 | NCEH1 (0.43) | NCEH1TACR3POLBCHRNB2CHRNB4 | |
| SCHEMBL9528133 | 0.83 | NCEH1 (0.37) | NCEH1POLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9528534 | 0.80 | TACR3 (0.42) | TACR3POLBCACNA2D1 | |
| SCHEMBL9528223 | 0.79 | TACR3 (0.41) | TACR3POLBCACNA2D1 | |
| SCHEMBL10369837 | 0.79 | GCGR (0.39) | TACR3POLBCACNA2D1 | |
| SCHEMBL9527611 | 0.79 | TACR3 (0.41) | TACR3CACNA2D1 | |
| SCHEMBL9528466 | 0.79 | TACR3 (0.41) | TACR3 | |
| SCHEMBL9528353 | 0.79 | TACR3 (0.41) | TACR3CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | claimed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | disclosed |