Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529876 | 0.94 | EPHX2 (0.38) | TACR3KDM4EMEN1RECQLKMT2A | |
| SCHEMBL9527527 | 0.94 | EPHX2 (0.38) | TACR3KDM4EMEN1RECQLKMT2A | |
| SCHEMBL9528223 | 0.92 | TACR3 (0.41) | TACR3CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL9528534 | 0.89 | TACR3 (0.42) | TACR3CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL9528353 | 0.87 | TACR3 (0.41) | TACR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9527611 | 0.87 | TACR3 (0.41) | TACR3KMT2AASAH1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9527595 | 0.86 | NCEH1 (0.42) | TACR3 | |
| SCHEMBL9527591 | 0.86 | FAAH (0.42) | TACR3 | |
| SCHEMBL9528680 | 0.84 | TACR3 (0.41) | TACR3KDM4EMEN1RECQLKMT2A | |
| SCHEMBL9527790 | 0.83 | TACR3 (0.41) | TACR3KMT2AALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | claimed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | claimed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | disclosed |