Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 5/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370877 | 0.92 | TACR3 (0.39) | TACR3FAAHGPR88POLB | |
| SCHEMBL9528223 | 0.90 | TACR3 (0.41) | TACR3FAAHCACNA2D1SMN1; SMN2GPR88 | |
| SCHEMBL9527611 | 0.89 | TACR3 (0.41) | TACR3CACNA2D1SMN1; SMN2NPC1LMNA | |
| SCHEMBL9528466 | 0.89 | TACR3 (0.41) | TACR3SMN1; SMN2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9528353 | 0.89 | TACR3 (0.41) | TACR3CACNA2D1SMN1; SMN2NPC1LMNA | |
| SCHEMBL9527591 | 0.88 | FAAH (0.42) | TACR3FAAHGPR88CNR2 | |
| SCHEMBL9527595 | 0.88 | NCEH1 (0.42) | TACR3FAAHCACNA2D1GPR88POLB | |
| SCHEMBL9528680 | 0.86 | TACR3 (0.41) | TACR3CACNA2D1NPC1LMNARAB9A | |
| SCHEMBL9527790 | 0.85 | TACR3 (0.41) | TACR3FAAHCACNA2D1GPR88POLB | |
| SCHEMBL9529632 | 0.85 | TACR3 (0.39) | TACR3SMN1; SMN2GPR88POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | claimed |
| JP-1250364-A | — | — | None | — | — | JP | disclosed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| JP-H01250364-A | ACYL DERIVATIVE OF HYDROXYPYRIMIDINES AND COMPOSITION THEREOF | PFIZER INC | 1989-10-05 | — | — | JP | disclosed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | disclosed |