Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 16/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 16/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 15/20 | 0.54 |
| ▸ | GABRA4 | P48169 | 13/20 | 0.54 |
| ▸ | GABRA6 | Q16445 | 13/20 | 0.54 |
| ▸ | GABRP | O00591 | 9/20 | 0.48 |
| ▸ | GABRD | O14764 | 9/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 9/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.48 |
| ▸ | GABRE | P78334 | 9/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 9/20 | 0.48 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835964 | 0.84 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9840075 | 0.84 | ALDH1A1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9075631 | 0.83 | GABRA1 (0.77) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9534278 | 0.82 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7502529 | 0.80 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9840344 | 0.78 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9840082 | 0.78 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9839096 | 0.77 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL11085907 | 0.77 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL10377163 | 0.77 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557497-A1 | NEW $g(b)-CARBOLIN DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-09-01 | — | — | EP | disclosed |
| WO-1993006100-A1 | NEW β-CARBOLIN DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-01 | — | — | WO | disclosed |