SCHEMBL9528465

SCHEMBL9528465

Cc1ccc(Cc2ccccc2C(=NO)c2ccncc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.41
KMT2A Q03164 1/20 0.41
TSHR P16473 2/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.37
SMN1; SMN2 Q16637 4/20 0.36
RAB9A P51151 3/20 0.36
NPC1 O15118 2/20 0.36
MAPT P10636 1/20 0.36
MAPK1 P28482 1/20 0.35
TP53 P04637 1/20 0.35
KDM4E B2RXH2 1/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10407004 0.89 TSHR (0.43) ALDH1A1KMT2ATSHRCYP3A4CYP2D6
SCHEMBL9528175 0.86 SMN1; SMN2 (0.40) ALDH1A1KMT2ATSHRCYP3A4CYP2D6
SCHEMBL10407865 0.86 ALDH1A1 (0.44) ALDH1A1KMT2ATSHRCYP3A4CYP2D6
SCHEMBL10733327 0.85 TSHR (0.47) ALDH1A1TSHRCYP3A4CYP2D6CYP2C19
SCHEMBL10406930 0.80 ALDH1A1 (0.46) ALDH1A1KMT2ATSHRSMN1; SMN2RAB9A
SCHEMBL9532053 0.80 NPC1 (0.43) ALDH1A1KMT2ATSHRCYP3A4CYP2D6
SCHEMBL9529021 0.77 SMN1; SMN2 (0.37) ALDH1A1KMT2ACYP3A4CYP2D6CYP2C19
SCHEMBL9528114 0.76 CYP2C9 (0.39) ALDH1A1KMT2ATSHRCYP3A4CYP2D6
SCHEMBL10407326 0.76 CYP2C19 (0.47) ALDH1A1CYP3A4CYP2D6CYP2C19SMN1; SMN2
SCHEMBL10406927 0.74 ALDH1A1 (0.44) ALDH1A1KMT2AL3MBTL1SMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0366006-B1 PYRIDYLKETOXIME ETHER COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT KAKEN PHARMACEUTICAL CO., LTD. (JP) 1993-09-29 EP disclosed
US-4971985-A ANTIISCHEMIC AGENTS, CARDIOVASCULAR DISORDERS KAKEN PHARMACEUTICAL CO., LTD. (JP) 1990-11-20 US disclosed