Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.95 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4322811 | 0.97 | PDE3B (1.00) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL29424272 | 0.97 | PDE3B (1.00) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8555995 | 0.91 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8552796 | 0.91 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8553283 | 0.91 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9038866 | 0.89 | PDE3B (0.84) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9670663 | 0.87 | KCNH2 (0.84) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9670657 | 0.87 | KCNH2 (0.84) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9038679 | 0.85 | PDE3B (0.70) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9638807 | 0.85 | KCNH2 (0.81) | PDE3BPDE3AKCNH2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294647-B1 | THIADIAZINONES | MERCK PATENT GmbH (DE) | 1993-07-21 | — | — | EP | disclosed |
| EP-0294647-A2 | Thiadiazinones | MERCK PATENT GmbH (DE) | 1988-12-14 | — | — | EP | disclosed |