Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.88 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29424272 | 0.93 | PDE3B (1.00) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL4322811 | 0.93 | PDE3B (1.00) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9528728 | 0.91 | PDE3B (0.95) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9038866 | 0.90 | PDE3B (0.84) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8555995 | 0.89 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8552796 | 0.89 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8557091 | 0.84 | PDE3B (0.63) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9670657 | 0.83 | KCNH2 (0.84) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9670663 | 0.83 | KCNH2 (0.84) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9039619 | 0.83 | PDE3B (0.72) | PDE3BPDE3AKCNH2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721950-B1 | Cardioactive 3-alkoxycarbonyl-thiadiazinones | MERCK PATENT GMBH (DE) | 1998-05-06 | — | — | EP | disclosed |
| EP-0721950-A2 | Cardioactive 3-alkoxycarbonyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-17 | — | — | EP | disclosed |