Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 8/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10517428 | 0.90 | OPRD1 (0.60) | OPRK1OPRD1OPRM1SIGMAR1 | |
| SCHEMBL10518193 | 0.90 | OPRD1 (0.60) | OPRK1OPRD1OPRM1SIGMAR1 | |
| SCHEMBL9529938 | 0.89 | OPRK1 (0.68) | OPRK1OPRD1 | |
| SCHEMBL9529600 | 0.89 | OPRD1 (0.72) | OPRK1OPRD1 | |
| SCHEMBL9528558 | 0.86 | OPRD1 (0.78) | OPRK1OPRD1 | |
| SCHEMBL10518719 | 0.85 | OPRD1 (0.55) | OPRK1OPRD1OPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9532360 | 0.85 | OPRD1 (0.77) | OPRK1OPRD1SIGMAR1 | |
| Fumaric Acid SCHEMBL10517419 | 0.84 | OPRD1 (0.66) | OPRK1OPRD1 | |
| Fumaric Acid SCHEMBL10517432 | 0.84 | OPRD1 (0.66) | OPRK1OPRD1 | |
| SCHEMBL9815269 | 0.82 | OPRD1 (0.83) | OPRK1OPRD1OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330360-B1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SMITHKLINE BEECHAM FARMA (IT) | 1993-12-01 | — | — | EP | claimed |
| EP-0330360-A1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1989-08-30 | — | — | EP | claimed |
| EP-0330469-A2 | Tetrahydroisoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |