Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531782 | 0.89 | HTR1A (0.53) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9527896 | 0.87 | HTR1A (0.62) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9526837 | 0.86 | HTR1A (0.58) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9528433 | 0.84 | HTR1A (0.55) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9528291 | 0.82 | HTR1A (0.63) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9527012 | 0.81 | HTR1A (0.56) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9531342 | 0.81 | HTR1A (0.60) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9527638 | 0.80 | HTR1A (0.61) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9527444 | 0.80 | HTR1A (0.60) | HTR1AADRA1AADRA1DADRA1BDRD4 | |
| SCHEMBL9526846 | 0.78 | ADRA1D (0.56) | HTR1AADRA1AADRA1DADRA1BDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |