Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.74 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | NQO2 | P16083 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531245 | 0.90 | MTNR1A (0.62) | HTR2AMTNR1AMTNR1BMEN1HPGD | |
| SCHEMBL24451304 | 0.85 | HTR2A (1.00) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 | |
| SCHEMBL30183412 | 0.85 | HTR2A (1.00) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 | |
| SCHEMBL9019785 | 0.84 | HTR2A (0.82) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 | |
| SCHEMBL4606963 | 0.84 | HTR2A (0.68) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 | |
| SCHEMBL18409742 | 0.83 | HTR2A (0.76) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 | |
| SCHEMBL29633095 | 0.82 | HTR2A (1.00) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 | |
| SCHEMBL25679654 | 0.82 | HTR2A (0.79) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 | |
| SCHEMBL1130014 | 0.82 | HTR2A (1.00) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 | |
| SCHEMBL25235496 | 0.82 | HTR2A (0.74) | HTR2AMTNR1ACYP1A2HTR1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| US-4886802-A | ANALGESICS | ROUSSEL UCLAF (FR) | 1989-12-12 | — | — | US | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |