Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 11/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529083 | 0.90 | HTR2A (0.74) | MTNR1AMTNR1BHTR2AKMT2AMEN1 | |
| SCHEMBL9527900 | 0.83 | HTR2A (0.58) | MTNR1AMTNR1BHTR2AHTR6MAPT | |
| SCHEMBL12352511 | 0.82 | HTR2A (0.79) | MTNR1AMTNR1BHTR2AKMT2AMEN1 | |
| SCHEMBL28079083 | 0.81 | MTNR1A (0.68) | MTNR1AMTNR1BHTR2AKMT2AMEN1 | |
| SCHEMBL2727889 | 0.81 | HTR2A (0.62) | MTNR1AMTNR1BHTR2AKMT2AMEN1 | |
| SCHEMBL1970281 | 0.80 | MTNR1A (0.63) | MTNR1AMTNR1BHTR2AKMT2AMEN1 | |
| SCHEMBL9559254 | 0.80 | MTNR1A (0.70) | MTNR1AMTNR1BHTR2AKMT2AMEN1 | |
| SCHEMBL10491369 | 0.78 | HTR2A (0.70) | HTR2AKMT2AMEN1 | |
| SCHEMBL13715395 | 0.78 | HTR2A (0.75) | MTNR1AMTNR1BHTR2AKMT2AMEN1 | |
| SCHEMBL4490583 | 0.77 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| US-4886802-A | ANALGESICS | ROUSSEL UCLAF (FR) | 1989-12-12 | — | — | US | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |