Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755547 | 0.87 | CYP2C9 (0.41) | CYP2C9HSD17B2PDGFRBPDGFRANPC1 | |
| SCHEMBL9232103 | 0.84 | CYP2C9 (0.40) | CYP2C9MAPTALDH1A1 | |
| SCHEMBL9262703 | 0.77 | CYP2C9 (0.46) | CYP2C9HSD17B2PDGFRBPDGFRANPC1 | |
| SCHEMBL10414589 | 0.76 | GAK (0.37) | CYP2C9NPC1RAB9AKMT2APDE2A | |
| SCHEMBL10415258 | 0.76 | NR3C1 (0.35) | CYP2C9KMT2APDE2AMAPTKDM4E | |
| SCHEMBL6474993 | 0.76 | CYP2C9 (0.38) | CYP2C9NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9232111 | 0.76 | CYP2C9 (0.40) | CYP2C9NPC1RAB9AMAPT | |
| SCHEMBL9529094 | 0.74 | CYP2C9 (0.34) | CYP2C9NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9544128 | 0.74 | CYP2C9 (0.41) | CYP2C9MAPTKDM4EALDH1A1 | |
| SCHEMBL9286732 | 0.74 | CYP2C9 (0.38) | CYP2C9NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535081-A1 | SUBSTITUTED BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AKTIEBOLAGET ASTRA (SE) | 1993-04-07 | — | — | EP | disclosed |