Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10415258 | 0.89 | NR3C1 (0.35) | CYP2C9ALDH1A1KMT2AKDM4EPDE2A | |
| SCHEMBL6474993 | 0.87 | CYP2C9 (0.38) | CYP2C9ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL9286732 | 0.87 | CYP2C9 (0.38) | CYP2C9ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL9529122 | 0.87 | CYP2C9 (0.41) | CYP2C9ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL9530345 | 0.86 | CYP2C9 (0.34) | CYP2C9ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL9529094 | 0.86 | CYP2C9 (0.34) | CYP2C9ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL10415267 | 0.85 | NR3C1 (0.35) | ALDH1A1MEN1KMT2ANPC1KDM4E | |
| SCHEMBL9532433 | 0.84 | CYP2C9 (0.32) | CYP2C9ALDH1A1KDM4EMAPTSLC22A2 | |
| SCHEMBL10416021 | 0.82 | ALDH1A1 (0.35) | CYP2C9ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL10416072 | 0.80 | SMN1; SMN2 (0.34) | CYP2C9MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019711-A1 | SUBSTITUTED BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AKTIEBOLAGET ASTRA (SE) | 1991-12-26 | — | — | WO | disclosed |