SCHEMBL9529188

SCHEMBL9529188

Cc1ccc(C#Cc2ccc3c(c2)C(C)(C)CC(C)(C)S3)nc1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.48
CYP26A1 O43174 2/20 0.48
RARA P10276 4/20 0.47
RARB P10826 4/20 0.47
RARG P13631 4/20 0.47
KMT2A Q03164 1/20 0.47
BACE1 P56817 6/20 0.35
BACE2 Q9Y5Z0 6/20 0.35
HSPA9 P38646 1/20 0.34
GRM5 P41594 2/20 0.34
CRABP2 P29373 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8892530 0.83 CYP3A4 (0.71) CYP3A4CYP26A1RARARARBRARG
SCHEMBL17885757 0.81 CYP3A4 (0.71) CYP3A4CYP26A1RARARARBRARG
SCHEMBL8875063 0.81 CYP3A4 (0.52) CYP3A4CYP26A1RARARARBRARG
SCHEMBL8865464 0.81 CYP3A4 (0.49) CYP3A4CYP26A1RARARARBRARG
SCHEMBL8630933 0.81 RARA (0.75) CYP3A4CYP26A1RARARARBRARG
SCHEMBL8874380 0.76 CYP3A4 (0.47) CYP3A4CYP26A1RARARARBRARG
SCHEMBL8875775 0.76 RARA (0.51) CYP3A4CYP26A1RARARARBRARG
SCHEMBL8558172 0.76 RARB (0.40) CYP3A4CYP26A1RARARARBRARG
SCHEMBL8865354 0.75 RARA (0.51) CYP3A4CYP26A1RARARARBRARG
SCHEMBL996873 0.73 CYP3A4 (0.70) CYP3A4CYP26A1RARARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0555235-A4 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY 1993-11-10 EP disclosed
EP-0555235-A1 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1993-08-18 EP disclosed
WO-1992006092-A1 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-04-16 WO disclosed