Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.70 |
| ▸ | RARB | P10826 | 10/20 | 0.54 |
| ▸ | RARG | P13631 | 10/20 | 0.54 |
| ▸ | RARA | P10276 | 8/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 7/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892530 | 0.91 | CYP3A4 (0.71) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL994761 | 0.86 | RARA (0.74) | CYP3A4CYP26A1RARBRARGRARA | |
| Tazarotenic Acid SCHEMBL29433140 | 0.82 | CYP3A4 (1.00) | CYP3A4CYP26A1RARBRARGRARA | |
| Tazarotenic Acid SCHEMBL29466098 | 0.82 | CYP3A4 (1.00) | CYP3A4CYP26A1RARBRARGRARA | |
| Tazarotenic Acid SCHEMBL678713 | 0.82 | CYP3A4 (1.00) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL995907 | 0.81 | CYP3A4 (0.70) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL5084210 | 0.81 | CYP3A4 (0.72) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL995437 | 0.80 | CYP3A4 (0.68) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL8890751 | 0.78 | CYP3A4 (0.59) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL8630933 | 0.77 | RARA (0.75) | CYP3A4CYP26A1RARBRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453746-A1 | TAZAROTENE DERIVATIVES | Stiefel Laboratories, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011009023-A1 | TAZAROTENE DERIVATIVES | STIEFEL LABORATORIES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |