Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9530444 | 0.83 | OPRM1 (0.41) | HTR2COPRM1HTR2B | |
| SCHEMBL9529776 | 0.80 | BCHE (0.41) | HTR2COPRM1POLB | |
| SCHEMBL9529130 | 0.78 | HTR2A (0.43) | HTR2COPRM1ALDH1A1PNMTOPRD1 | |
| SCHEMBL9530729 | 0.78 | HTR2C (0.43) | HTR2COPRM1MAPTKDM4EALDH1A1 | |
| Bromide SCHEMBL9529223 | 0.77 | KDM1A (0.45) | OPRM1MAPTKDM4E | |
| SCHEMBL3453173 | 0.77 | OPRM1 (0.56) | OPRM1SMN1; SMN2KDM4EALDH1A1SLC22A1 | |
| SCHEMBL329828 | 0.75 | OPRM1 (0.57) | OPRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL329925 | 0.75 | OPRM1 (0.57) | OPRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL330238 | 0.75 | OPRM1 (0.57) | OPRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL9528729 | 0.72 | HTR2A (0.44) | HTR2COPRM1MAPTKCNH2OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330360-B1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SMITHKLINE BEECHAM FARMA (IT) | 1993-12-01 | — | — | EP | disclosed |
| US-4954509-A | Isoquinoline derivatives and their use as analgesics | DR. LO. ZAMBELETTI S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |