Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 10/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9530444 | 0.80 | OPRM1 (0.41) | HTR1AOPRM1HTR2CDRD2 | |
| SCHEMBL9529191 | 0.80 | HTR2C (0.43) | POLBOPRM1HTR2C | |
| SCHEMBL9529211 | 0.80 | SIGMAR1 (0.48) | HTR1A | |
| SCHEMBL2795781 | 0.79 | HTR1A (0.50) | HTR1AOPRM1HTR2CDRD2 | |
| SCHEMBL9530051 | 0.79 | SIGMAR1 (0.50) | HTR1A | |
| SCHEMBL23959518 | 0.78 | HTR2C (0.45) | OPRM1HTR2C | |
| SCHEMBL24174623 | 0.78 | HTR2C (0.45) | OPRM1HTR2C | |
| SCHEMBL30422600 | 0.78 | HTR2C (0.45) | OPRM1HTR2C | |
| SCHEMBL3452409 | 0.76 | BCHE (0.58) | BCHEACHE | |
| SCHEMBL9529368 | 0.74 | BCHE (0.48) | BCHEACHEOPRM1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330360-B1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SMITHKLINE BEECHAM FARMA (IT) | 1993-12-01 | — | — | EP | disclosed |
| US-4954509-A | Isoquinoline derivatives and their use as analgesics | DR. LO. ZAMBELETTI S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0330360-A1 | 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1989-08-30 | — | — | EP | disclosed |