Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 6/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529704 | 0.88 | DRD2 (0.38) | DRD2DRD4DRD3 | |
| SCHEMBL9532364 | 0.86 | DRD2 (0.36) | DRD2DRD4DRD3 | |
| SCHEMBL9528467 | 0.86 | RAB9A (0.42) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9528137 | 0.81 | DRD2 (0.53) | DRD2DRD4DRD3 | |
| SCHEMBL9528676 | 0.79 | DRD2 (0.37) | DRD2DRD4DRD3GABRA5CYP11B1 | |
| SCHEMBL9528065 | 0.74 | DRD2 (0.35) | DRD2DRD4DRD3 | |
| SCHEMBL8907983 | 0.74 | DRD2 (0.66) | DRD2DRD4DRD3 | |
| SCHEMBL9529758 | 0.72 | DRD2 (0.38) | DRD2DRD4DRD3F2 | |
| SCHEMBL9529877 | 0.71 | DRD2 (0.49) | DRD2DRD4DRD3 | |
| SCHEMBL9529734 | 0.70 | DRD2 (0.52) | DRD2DRD4DRD3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556332-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | claimed |
| EP-0556332-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | disclosed |