Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PHGDH | O43175 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277778 | 0.81 | ALDH1A1 (0.41) | CYP1A2CYP3A4CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL5632525 | 0.71 | CYP1A2 (0.46) | CYP1A2CYP3A4CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL9350805 | 0.69 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL9353590 | 0.69 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL9528983 | 0.67 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL11717863 | 0.66 | KMT2A (0.41) | CYP1A2CYP3A4CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL470176 | 0.64 | KEAP1 (0.38) | ALDH1A1POLBKEAP1 | |
| SCHEMBL3057133 | 0.64 | ALDH1A1 (0.44) | ALDH1A1POLBKEAP1 | |
| SCHEMBL3101559 | 0.63 | ALDH1A1 (0.40) | ALDH1A1POLBKEAP1MEN1KMT2A | |
| SCHEMBL6420253 | 0.63 | KEAP1 (0.37) | ALDH1A1POLBKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307084-B1 | Substituted thieno(2,3-b)thiophene-2-sulfonamides as antiglaucoma agents | MERCK & CO INC (US) | 1993-12-15 | — | — | EP | disclosed |
| EP-0541705-A4 | SUBSTITUTED 1H-IMIDAZOL-5-YL)ALKANOIC ACIDS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0541705-A1 | SUBSTITUTED 1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| EP-0366178-B1 | 5-[N-methoxyethyl-N-methoxyethoxyethyl)aminomethyl]thieno [2,3-b] thiophene-2-sulfonamide as antiglaucoma agents | MERCK & CO. INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| EP-0366178-A1 | 5-[N-methoxyethyl-N-methoxyethoxyethyl)aminomethyl]thieno [2,3-b] thiophene-2-sulfonamide as antiglaucoma agents | MERCK & CO. INC. (US) | 1990-05-02 | — | — | EP | disclosed |
| US-4894390-A | VISION DEFECTS | MERCK & CO., INC. (US) | 1990-01-16 | — | — | US | disclosed |
| EP-0307084-A1 | Substituted thieno(2,3-b)thiophene-2-sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1989-03-15 | — | — | EP | disclosed |
| US-4806562-A | Substituted thieno[2,3-b]thiophene-2-sulfonamides as antiglaucoma agents | MERCK & CO., INC. (US) | 1989-02-21 | — | — | US | disclosed |