Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126366 | 0.86 | SLC6A3 (0.58) | SLC6A3SLC6A4SLC6A2BDKRB1HIF1A | |
| SCHEMBL20183881 | 0.83 | CA1 (0.57) | HIF1AHDAC1HDAC8HDAC6PPARG | |
| SCHEMBL29879594 | 0.81 | CA1 (0.61) | HIF1AHDAC1PPARGPPARDPPARA | |
| SCHEMBL15761747 | 0.81 | CA1 (0.61) | HIF1AHDAC1PPARGPPARDPPARA | |
| SCHEMBL10055018 | 0.79 | NOS1 (0.63) | KDM4EGAAHIF1AHDAC1HDAC8 | |
| SCHEMBL10055048 | 0.78 | NOS1 (0.56) | KDM4EGAAHIF1AHDAC1HDAC8 | |
| SCHEMBL30285198 | 0.78 | SLC6A3 (0.66) | KDM4EGAASLC6A3SLC6A4SLC6A2 | |
| SCHEMBL9534641 | 0.78 | HDAC1 (0.48) | KDM4EGAAHIF1ACYP1A2CYP2D6 | |
| SCHEMBL6276231 | 0.77 | SLC6A3 (0.71) | KDM4EGAASLC6A3SLC6A4SLC6A2 | |
| SCHEMBL14689659 | 0.77 | MAPT (0.64) | KDM4EGAAHIF1AHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |