Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20768161 | 0.75 | P2RY6 (0.33) | ABCG2ITGB2ICAM1ITGALP2RY6 | |
| SCHEMBL9531349 | 0.75 | POLB (0.40) | HPGDPOLBNPC1RAB9AMAPT | |
| SCHEMBL22554927 | 0.75 | CREBBP (0.44) | BRD4CREBBPKDM4EALDH1A1AKR1B1 | |
| SCHEMBL5884655 | 0.72 | MAOB (0.47) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9532685 | 0.72 | POLB (0.38) | HPGDPOLBMAPTSMN1; SMN2 | |
| SCHEMBL30124141 | 0.71 | BRD4 (0.40) | BRD4CREBBPKDM4EALDH1A1HPGD | |
| SCHEMBL8605993 | 0.69 | BRD4 (0.42) | BRD4CREBBPKDM4EALDH1A1HPGD | |
| SCHEMBL6639183 | 0.69 | SIRT1 (0.43) | POLBMEN1KMT2ANISCH | |
| SCHEMBL158578 | 0.66 | — | — | |
| SCHEMBL24214454 | 0.65 | NISCH (0.46) | BRD4CREBBPALDH1A1AKR1B1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277384-A2 | 1H-imidazole-5-carboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-08-10 | — | — | EP | claimed |
| EP-0314852-B1 | Process for the preparation of 1-substituted imidazole-carbonic acid and derivatives | CIBA GEIGY AG (CH) | 1993-11-18 | — | — | EP | disclosed |
| US-4921955-A | Process for the synthesis of 1-substituted imidazole-5-carboxylic acids and carboxylic acid derivatives | CIBA-GEIGY CORPORATION (US) | 1990-05-01 | — | — | US | disclosed |
| EP-0314852-A2 | Process for the preparation of 1-substituted imidazole-carbonic acid and derivatives | CIBA-GEIGY AG (CH) | 1989-05-10 | — | — | EP | disclosed |
| EP-0277384-A2 | 1H-imidazole-5-carboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-08-10 | — | — | EP | disclosed |