Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533840 | 0.88 | AGTR1 (0.48) | ALDH1A1CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL9531455 | 0.80 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL9532747 | 0.77 | AGTR1 (0.58) | AGTR1AGTR2 | |
| SCHEMBL9688840 | 0.77 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL9688848 | 0.77 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL9688845 | 0.75 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL2127 | 0.72 | SCN1A (0.50) | ALDH1A1CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL3202 | 0.70 | SCN1A (0.51) | ALDH1A1CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL9532191 | 0.70 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9533449 | 0.69 | AGTR1 (0.55) | AGTR1ACHEAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |