Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 2/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202 | 0.90 | SCN1A (0.51) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL2302 | 0.88 | SCN1A (0.51) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL8872170 | 0.85 | ALDH1A1 (0.63) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL2117 | 0.84 | SCN1A (0.45) | SCN1ASCN2ASCN3AALDH1A1TSHR | |
| SCHEMBL1615 | 0.84 | SCN1A (0.51) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL8873461 | 0.82 | TSHR (0.65) | SCN1ASCN2ASCN3AALDH1A1TSHR | |
| SCHEMBL8873262 | 0.81 | TSHR (0.61) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL8872472 | 0.80 | SLC6A3 (0.48) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL3020 | 0.79 | SCN1A (0.42) | SCN1ASCN2ASCN3ACYP3A4MAPK1 | |
| SCHEMBL8873252 | 0.79 | SLC6A3 (0.50) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |