SCHEMBL953062

SCHEMBL953062

Cc1cc(Cl)cc(C(=O)NN)c1NC(=O)c1cc(Br)cn1-c1cccnc1Cl

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.37
F10 P00742 1/20 0.35
GRM4 Q14833 3/20 0.35
DRD4 P21917 1/20 0.34
MAPT P10636 5/20 0.34
RAB9A P51151 2/20 0.33
NPC1 O15118 1/20 0.33
DRD2 P14416 1/20 0.33
DRD1 P21728 1/20 0.33
POLB P06746 2/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
ALDH1A1 P00352 3/20 0.33
HPGD P15428 1/20 0.32
SORT1 Q99523 1/20 0.32
TP53 P04637 2/20 0.32
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528713 0.92 F10 (0.36) F10GRM4DRD4MAPTRAB9A
SCHEMBL14495039 0.90 GFER (0.37) F10GRM4MAPTRAB9ANPC1
SCHEMBL12911754 0.89 GFER (0.35) F10GRM4DRD4MAPTRAB9A
SCHEMBL27727887 0.88 GRM5 (0.35) P2RX7F10RAB9ADRD2DRD1
SCHEMBL13072879 0.88 ALDH1A1 (0.35) F10GRM4MAPTRAB9ANPC1
SCHEMBL951506 0.87 MALT1 (0.37) P2RX7F10GRM4DRD4RAB9A
SCHEMBL12559401 0.86 F10 (0.33) F10GRM4MAPTRAB9ANPC1
SCHEMBL951524 0.84 F10 (0.34) F10MAPTSMN1; SMN2ALDH1A1HPGD
SCHEMBL950577 0.82 F10 (0.38) F10MAPTPOLBSMN1; SMN2ALDH1A1
SCHEMBL950524 0.79 PDE4A (0.34) F10ALDH1A1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 P2RX7 926/4885F10 2564/4885GRM4 1309/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT P2RX7 1292/4885F10 3713/4885GRM4 861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.