Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28879401 | 0.89 | ALDH1A1 (0.60) | ALDH1A1RECQLMMP8POLBNPSR1 | |
| SCHEMBL12555524 | 0.81 | POLB (0.65) | ALDH1A1RECQLMMP8POLBNPSR1 | |
| SCHEMBL27493575 | 0.79 | ALDH1A1 (0.54) | ALDH1A1RECQLMMP8PTPN1PTPN2 | |
| SCHEMBL25953192 | 0.79 | MMP8 (0.55) | ALDH1A1RECQLMMP8PIN1KMT2A | |
| SCHEMBL17027466 | 0.77 | ALDH1A1 (0.57) | ALDH1A1RECQLMMP8POLBNPSR1 | |
| SCHEMBL17617120 | 0.77 | ALDH1A1 (0.53) | ALDH1A1RECQLMMP8PTPN1PTPRC | |
| SCHEMBL2269978 | 0.77 | ALDH1A1 (0.53) | ALDH1A1RECQLMMP8NPSR1PIN1 | |
| SCHEMBL30513307 | 0.77 | ALDH1A1 (0.60) | ALDH1A1RECQLMMP8POLBNPSR1 | |
| SCHEMBL7944901 | 0.77 | ALDH1A1 (0.56) | ALDH1A1PTPN1PTPRCKMT2AMEN1 | |
| SCHEMBL8661661 | 0.77 | MMP8 (0.60) | ALDH1A1RECQLMMP8POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252744-B1 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | LILLY CO ELI (US) | 1993-12-15 | — | — | EP | disclosed |
| US-4734498-A | 3β-succinimidoazetidinones as chiral intermediates | ELI LILLY AND COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0252744-A2 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | ELI LILLY AND COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |