Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214006 | 0.79 | GPBAR1 (0.40) | GPBAR1LMNAMAP3K14GAANPC1 | |
| SCHEMBL7382228 | 0.79 | ACE2 (0.43) | GPBAR1GAANPC1RAB9AMEN1 | |
| SCHEMBL9213182 | 0.77 | CYP19A1 (0.39) | GPBAR1LMNAMAP3K14GAANPC1 | |
| SCHEMBL8954174 | 0.77 | GPBAR1 (0.38) | GPBAR1LMNAMAP3K14GAANPC1 | |
| Hydrochloric Acid SCHEMBL8971928 | 0.76 | CYP19A1 (0.38) | GPBAR1LMNAMAP3K14GAANPC1 | |
| SCHEMBL9092959 | 0.76 | CYP11B1 (0.52) | GPBAR1GAACYP11B1CYP11B2 | |
| SCHEMBL7383288 | 0.71 | ACE2 (0.41) | — | |
| SCHEMBL20534707 | 0.69 | MEN1 (0.48) | GAAMEN1KMT2A | |
| SCHEMBL5869963 | 0.68 | ACE2 (0.68) | GPBAR1GAAKMT2ACYP11B1CYP11B2 | |
| SCHEMBL1951714 | 0.68 | CYP11B1 (0.69) | LMNARAB9AMEN1KMT2ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0541705-A4 | SUBSTITUTED 1H-IMIDAZOL-5-YL)ALKANOIC ACIDS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0541705-A1 | SUBSTITUTED 1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |