Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530832 | 1.00 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9530830 | 1.00 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9531495 | 0.86 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL10543412 | 0.86 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL10538984 | 0.86 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9531501 | 0.86 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9529808 | 0.86 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9530450 | 0.83 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9530480 | 0.83 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9530475 | 0.83 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214743-B1 | USE OF QUINOLINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS AND CEREBRAL SENILITY | BEECHAM GROUP PLC (GB) | 1993-05-12 | — | — | EP | claimed |
| EP-0150202-B1 | DI/TETRA-HYDROQUINOLINES | BEECHAM GROUP PLC (GB) | 1988-07-06 | — | — | EP | claimed |
| EP-0214743-A2 | Use of quinoline derivatives in the manufacture of medicaments for the treatment of cerebrovascular disorders and cerebral senility | BEECHAM GROUP PLC (GB) | 1987-03-18 | — | — | EP | claimed |
| US-4808619-A | HYPOTENSIVE AGENT, COGNITION ACTIVATOR | BEECHAM GROUP P.L.C. (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0150202-B1 | DI/TETRA-HYDROQUINOLINES | BEECHAM GROUP PLC (GB) | 1988-07-06 | — | — | EP | disclosed |