Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.55 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532603 | 0.91 | AGTR1 (0.66) | AGTR1AGTR2PPARG | |
| SCHEMBL9531605 | 0.89 | AGTR1 (0.56) | AGTR1AGTR2ACHEPPARG | |
| SCHEMBL9533553 | 0.86 | AGTR1 (0.55) | AGTR1AGTR2ACHE | |
| SCHEMBL8885452 | 0.84 | AGTR1 (0.64) | AGTR1AGTR2PPARG | |
| SCHEMBL9533449 | 0.82 | AGTR1 (0.55) | AGTR1AGTR2ACHE | |
| SCHEMBL8410153 | 0.82 | AGTR1 (0.61) | AGTR1AGTR2ACHEPPARG | |
| SCHEMBL9534135 | 0.82 | PPARG (0.56) | AGTR1AGTR2ACHEPPARG | |
| SCHEMBL9136699 | 0.81 | AGTR1 (0.55) | AGTR1AGTR2ACHE | |
| SCHEMBL9844182 | 0.80 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL9427397 | 0.79 | AGTR1 (0.61) | AGTR1AGTR2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |