Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metronidazole SCHEMBL9833775 | 0.80 | LMNA (0.61) | KMT2ALMNATHRBCA12CA1 | |
| SCHEMBL28818918 | 0.78 | KMT2A (0.48) | KMT2ALMNATHRBCYP2C19TYMP | |
| SCHEMBL2360743 | 0.74 | KMT2A (0.43) | KMT2ALMNATHRBCYP2C19TYMP | |
| SCHEMBL16896833 | 0.74 | LMNA (0.33) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL296106 | 0.73 | LMNA (0.48) | KMT2ALMNATHRBCYP2C19TYMP | |
| SCHEMBL27795012 | 0.73 | KMT2A (0.44) | KMT2ALMNATHRBCYP2C19TYMP | |
| SCHEMBL11805067 | 0.73 | LMNA (0.37) | KMT2ALMNATHRBCYP2C19TYMP | |
| SCHEMBL3835020 | 0.71 | LMNA (0.43) | KMT2ALMNATHRBCYP2C19TYMP | |
| SCHEMBL3937885 | 0.71 | KMT2A (0.37) | KMT2ALMNATHRBCYP2C19TYMP | |
| SCHEMBL10400098 | 0.71 | KMT2A (0.45) | KMT2ALMNATHRBCYP2C19TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325513-B1 | PROCESS FOR THE PREPARATION OF 1-HYDROXYALKYL-2-METHYL-5-NITRO-IMIDAZOLES | RHONE-POULENC SANTE (FR) | 1993-04-07 | — | — | EP | claimed |
| EP-0324691-B1 | PROCESS FOR THE PREPARATION OF 1-HYDROXYALKYL-5-NITRO-IMIDAZOLES | RHONE-POULENC SANTE (FR) | 1991-12-27 | — | — | EP | claimed |
| US-4925951-A | Process for preparing 1-hydroxyalkyl-2-methyl-5-nitroimidazoles | RHONE-POULENC SANTE (FR) | 1990-05-15 | — | — | US | claimed |
| US-4925952-A | Process for preparing 1-hydroxyalkyl-5-nitroimidazoles | RHONE-POULENC SANTE (FR) | 1990-05-15 | — | — | US | claimed |
| JP-2000766-A | — | — | None | — | — | JP | disclosed |
| CN-106977501-A | A kind of hypoxemia activation prodrug based on the alkylol of 2 nitroimidazole 1 | 华东师范大学 | 2017-07-25 | — | — | CN | disclosed |
| CN-1023318-C | Process for preparing 1-hydroxyalkyl-5-nitro imidazoles | RHONE POULENC SANTE (FR) | 1993-12-29 | — | — | CN | disclosed |
| CN-1023220-C | Process for preparing 1-hydroxyalkyl-2-methyl-5-nitro imidazoles | RHONE POULENC SANTE (FR) | 1993-12-22 | — | — | CN | disclosed |
| US-5023361-A | Process for preparing hydroxyalkylating agents, the agents so obtained, and their use | RHONE-POULENC SANTE (FR) | 1991-06-11 | — | — | US | disclosed |
| US-4925950-A | Process for preparing 1-hydroxyalkyl-5-nitroimidazole | RHONE-POULENC SANTE (FR) | 1990-05-15 | — | — | US | disclosed |
| US-4925951-A | Process for preparing 1-hydroxyalkyl-2-methyl-5-nitroimidazoles | RHONE-POULENC SANTE (FR) | 1990-05-15 | — | — | US | disclosed |
| US-4925951-A | Process for preparing 1-hydroxyalkyl-2-methyl-5-nitroimidazoles | RHONE-POULENC SANTE (FR) | 1990-05-15 | — | — | US | disclosed |
| US-4925952-A | Process for preparing 1-hydroxyalkyl-5-nitroimidazoles | RHONE-POULENC SANTE (FR) | 1990-05-15 | — | — | US | disclosed |
| US-4925952-A | Process for preparing 1-hydroxyalkyl-5-nitroimidazoles | RHONE-POULENC SANTE (FR) | 1990-05-15 | — | — | US | disclosed |
| JP-H02766-A | PREPARATION OF HYDROXYALKYLATION AGENT, HYDROXYLKYLATION AGENT OBTAINED AND METHOD FOR USING IT | RHONE POULENC SANTE | 1990-01-05 | — | — | JP | disclosed |