Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.61 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.61 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.61 |
| ▸ | MLNR known ✓ | O43193 | 1/20 | 0.61 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.61 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.61 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.61 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.61 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.61 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.61 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.61 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.61 |
| ▸ | DRD1 | P21728 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9531472 | 1.00 | CHRM2 (0.61) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL14282957 | 0.94 | BCHE (0.67) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Fumaric Acid SCHEMBL9353277 | 0.92 | CHRM2 (0.56) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Fumaric Acid SCHEMBL9353275 | 0.92 | CHRM2 (0.56) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Fumaric Acid SCHEMBL9353334 | 0.91 | BCHE (0.65) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Fumaric Acid SCHEMBL9352958 | 0.91 | BCHE (0.57) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Fumaric Acid SCHEMBL9352967 | 0.91 | BCHE (0.57) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Fumaric Acid SCHEMBL9353324 | 0.91 | BCHE (0.65) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Fumaric Acid SCHEMBL10764331 | 0.90 | ADRA1A (0.73) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Fumaric Acid SCHEMBL10764324 | 0.90 | ADRA1A (0.73) | CHRM2HTR1AADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335586-B1 | PIPERIDINE & PIPERAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UBE INDUSTRIES, LTD. (JP) | 1993-06-02 | — | — | EP | disclosed |