Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690851 | 0.81 | PPARG (0.44) | PPARGCNR1PDE9APDE1C | |
| SCHEMBL14208362 | 0.81 | PPARG (0.48) | PPARGDPP4CNR1PDE9APDE1C | |
| SCHEMBL9690284 | 0.79 | MAPK8 (0.46) | PPARG | |
| SCHEMBL9690123 | 0.77 | ALOX5AP (0.46) | PPARGCNR1 | |
| SCHEMBL1890010 | 0.74 | PPARG (0.48) | PPARGDPP4CNR1PDE9APDE1C | |
| SCHEMBL1888964 | 0.74 | PPARG (0.64) | PPARG | |
| SCHEMBL8804016 | 0.74 | PPARG (0.48) | PPARGDPP4CNR1 | |
| SCHEMBL1887155 | 0.74 | PPARG (0.48) | PPARGDPP4CNR1PDE9APDE1C | |
| SCHEMBL1890122 | 0.72 | PPARG (0.61) | PPARG | |
| SCHEMBL4012027 | 0.72 | PPARG (0.63) | PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |