Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690123 | 0.91 | ALOX5AP (0.46) | ALOX5APPPARGMEN1KMT2A | |
| SCHEMBL9690851 | 0.86 | PPARG (0.44) | ALOX5APPPARG | |
| SCHEMBL9531841 | 0.85 | PPARG (0.52) | MAPK8PPARGPLA2G2A | |
| SCHEMBL9536684 | 0.84 | MAPK8 (0.55) | MAPK8PPARGPLA2G2AEGLN1HDAC1 | |
| SCHEMBL9531601 | 0.80 | MAPK8 (0.43) | MAPK8PLA2G2AEGLN1HDAC1HDAC8 | |
| SCHEMBL9531997 | 0.79 | PPARG (0.45) | PPARG | |
| SCHEMBL9531469 | 0.76 | PPARG (0.49) | PPARG | |
| SCHEMBL9531904 | 0.74 | PPARG (0.50) | PPARGPLA2G2A | |
| SCHEMBL14208362 | 0.73 | PPARG (0.48) | PPARG | |
| SCHEMBL9530978 | 0.72 | PPARG (0.51) | PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |